学部・大学院区分

理学部

時間割コード

0681180

科目区分

専門科目
Specialized Courses

科目名　【日本語】

有機化学３

科目名　【英語】

Organic Chemistry III

コースナンバリングコード

担当教員　【日本語】

SHIN Jiyoung ○

担当教員　【英語】

SHIN Jiyoung ○

単位数

開講期・開講時間帯

秋火曜日１時限
Fall Tue 1

授業形態

講義
Lecture

学科・専攻

G30 Chemistry

必修・選択

* See "Remarks"

授業の目的　【日本語】

The main purpose of the course is to acquire a logical framework for understanding fundamental organic chemistry. This framework can provide an influence on the reactions of the organic compounds having important functional groups, such as hydroxy, carbonyl, and amino groups and the reactions of their derivatives. On the basis of the knowledge, how to solve practical problems is learned sequentially.

授業の目的　【英語】

到達目標　【日本語】

On the basis of the knowledge, how to perceive appropriate answers of challenging problems in organic chemistry is encountered.

到達目標　【英語】

授業の内容や構成

Class 1 & 2. Alcohols and Ethers --- Acidity/Basicity of Alcohols; Preparation of Alcohols (Nucleophilic Substitutions (SN1 & SN2), Reduction of Carbonyl Compounds, Hydrolysis of Esters); Reaction of Alcohols (Deprotonation, Substitution, Elimination, Oxidation, Inorganic Ester Formation); Preparation of Ethers (Williamson Ether Synthesis) and Reaction of Ethers
Class 3. Esters --- Inorganic and Organic Esters; Haloalkane Formation from Alcohols via Inorganic Esters; Reaction of Organic Esters (Hydrolysis, Lactones into Open Chain Ester, Esters into Amides and Alcohols, Reduction)
Class 4. Acyl Halide --- Reactivity of Carbonyl Compounds (Leaving Ability of Leaving Groups); Reaction of Acyl Halides (Conversion into Carboxylic acid, Anhydride, Ester, Amide, Ketone, Aldehyde, and Phenylalkanone)
Class 5. Aldehydes and Ketones --- Preparations of Aldehydes and Ketones (Oxidation of Alcohols, Ozonolysis of Alkenes, Hydration of Alkyenes; Friedel-Grafts Acylation)
Class 6. Reactions of Aldehydes and Ketones --- Grignard Reaction; Hydration (in acid/base); Acetalization/Deacetalization; Thioacetalization/Dethioacetalization/Desulfurization
Class 7. Reactions of Aldehydes and Ketones --- Conversions into Cyanohydrin; Wittig Reaction; Baeyer-Villiger Oxidation; Conversion into Imine, Oxime, and Hydrazone; Reduction of Acyl Compounds into Alkanes
Class 8. Assessment of the Classes 1-7 with Practice Problems
Class 9. Enols and Enolates --- Reactivity and Reaction Trends of Carbonyl Compounds in Acid and Base
Class 10. Reactivities of Formaldehyde, Aldehydes and Ketones and Their Reactions --- Reactions with Amines (into Imine, Iminium, and Enamine) and Reaction Comparison; Mannich Reaction
Class 11. Reactions of Conjugated Aldehydes, Ketones, --- Preparation of Conjugate Carbonyl Compounds; 1,2-additon versus 1,4-addition; Soft and Hard Base Nucleophiles; Michael Additions; Robison Anuulation
Class 12. Carboxylic Acids --- Preparation of Carboxylic acids (Alcoholysis, Hydrolysis, Over Oxidation of Primary Alcohols, Reduction of CO2, Conversion of Nitrile into Carboxylic Acid)
Class 13. Reactions of Carboxylic Acids --- Hell-Volhard-Zelinsky Bromination; Acyl Chloride Formation; Anhydride Formation; Decarboxylation
Class 14. Intermolecular/Intramolecular Cross Condensations --- Aldol Condensation; Claisen Condensation; Retro-Claisen Condensation; Deackmann Condensation
Class 15. Assessment of Overall Classes (1-14) with Practice Problems

履修条件

Fundamentals of Chemistries I and II, Organic Chemistries I and II