授業の目的 【日本語】
Goals of the Course(JPN) | | | 有機化学１の主目的は有機化学を始まる学生達に基礎有機化学に対する理解度を高めるための論理フレームワークを構築することである。したがって、本科目では有機分子構造と電子密度構成が化学反応のパターンにどのように関連しているかを特に強調している。 |
|
|
授業の目的 【英語】
Goals of the Course | | | The primary purpose of this course is to help students build a logical framework for understanding fundamental organic chemistry. Therefore, this course emphasizes how the organic molecular structures and the electron density compositions are related to patterns of organic chemical reactions. |
|
|
到達目標 【日本語】
Objectives of the Course(JPN)) | | | 参加者は、コースの内容を通じて学んだ知識に基づいて、分子内または分子間で発生する有機反応のメカニズムを調査し、反応シーケンスの進行性の問題を解決できると期待される。 |
|
|
到達目標 【英語】
Objectives of the Course | | | Participants are expected to investigate the mechanism of intramolecular or intermolecular organic reactions and solve the problem of progressive reaction sequences based on the knowledge learned through the course contents. |
|
|
授業の内容や構成
Course Content / Plan | | Class 1. Structure Perspective of Organic Molecules --- Atomic Electron Configuration and Construction of Organic Molecules (Hybridization).
Class 2. Projection of Molecular Structures of Organic Molecules and Classification of the Isomers --- Constitutional (Chain, Position, and Functional Group) Isomers and Stereoisomers (Diastereomers and Enantiomers).
Class 3. Optical Activities of Stereoisomers and Assignment of Stereoisomeric Structures --- Fischer and Newman Projections; Absolute (R/S) and Optically Observed (D/L) Rotations; Specific Rotation and Enantiomeric Purity; Meso Compound.
Class 4. Electron Density Configuration of Organic Molecules and Their Acidity/Basicity --- Formal Charges and Oxidation States; Acidity/Basicity and Electrophilicity/Nucleophilicity; Type of Chemical Reactions.
Class 5. Potential Energy Profiles for Kinetically and Thermodynamically Favorable Reactions --- Stability of Carbocations, Carbanions, Hydrocarbon Radicals, and the Stabilization Factors (Hyperconjugation and Resonance).
Class 6. Assessment of the Classes 1-5 with Practice Problems.
Class 7. General Trends of Aliphatic Nucleophilic Substitutions and Bimolecular Reactions (SN2) --- Efficient Substrates and Proper Leaving Groups; Reactivity of Nucleophiles and Solvent Effect; Stereochemistry; Competing Reactions.
Class 8. Unimolecular Aliphatic Nucleophilic Substitutions (SN1) --- Efficient Substrates and Proper Leaving Groups; Nucleophilicity and Solvolysis; Stability of Carbocation Intermediate; Stereochemistry; Competing Reactions.
Class 9. Aliphatic Eliminations --- Unimolecular (E1 and E1CB) and Bimolecular (E2) Elimination; Thermodynamically and Kinetically favored (Zaitsev and Hofmann) Eliminations.
Class 10. Types of Nucleophiles and Haloalkanes and Their Reaction Trends/Overview (Substitutions & Eliminations).
Class 11. Assessment of the Classes 7-10 with Practice Problems.
Class 12. Nomenclature of Organic Compounds --- Saturated/Unsaturated Hydrocarbons; Functional Groups; Aromatic Hydrocarbons; Stereochemical Assignments; Fused Rings (Spiroalkanes and Bicyclo/Tricycloalkanes).
Class 13. Structures and Stereochemistry of Cycloalkanes and their Stability and Reactivity.
Class 14. Preparation of Haloalkanes (Radical Reactions) --- Potential Energy Profiles of Reaction Coordinates.
Class 15. Assessment of Overall Classes with Practice Problems (1-14). |
|
|
履修条件
Course Prerequisites | | | Fundamentals of Chemistry I and II |
|
|
関連する科目
Related Courses | | |
|
成績評価の方法と基準
Course Evaluation Method and Criteria | | | Examination [Total 70%: two midterms (20% for each) and one final (30%)] and Assignment and attendance (30%): A+(>95), A(95>x>x80), B(80>x>70), C(70>x>65), C-(65>x>60), and F(60>x). The assessment methods will be reconsidered due to the change of the pandemic condition. |
|
|
不可(F)と欠席(W)の基準
Criteria for "Fail (F)" & "Absent (W)" grades | | | The student needs to contact the course instructor when the student wants to withdraw from the course. No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s). |
|
|
参考書
Reference Book | | | Organic Chemistry (second edition), Jonathan Clayden, Nick Greeves, and Stuart Warren (Oxford University Press), 2012 ISBN-10:0199270295. |
|
|
教科書・テキスト
Textbook | | | Organic Chemistry: Structure and Function (Seventh Edition), Peter C. Vollhardt and Neil E. Schore, (W. H. Freeman and Company), New York, 2014, Chapters 1-7. |
|
|
課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours) | | | Students are recommended to prepare each lecture by reading the corresponding chapter in the textbook. Also, Students are recommended to review it by solving the related homework questions. Each assignment is due by the start of the next class. Late or no submission of the assignment is the deduction point of the grade. |
|
|
注意事項
Notice for Students | | |
|
他学科聴講の可否
Propriety of Other department student's attendance | | | Chemistry and biology students are the majority. The course participants should have completed the fundamentals of chemistry courses at least. |
|
|
他学科聴講の条件
Conditions for Other department student's attendance | | | The course instructor will attempt to provide faired circumstances for all course participants. |
|
|
レベル
Level | | |
|
キーワード
Keyword | | |
|
履修の際のアドバイス
Advice | | |
|
授業開講形態等
Lecture format, etc. | | | Each lecture is provided in a PowerPoint projection. Participants will obtain lecture materials corresponding to each class through NUCT. Also, sudden questions will be given to students during lectures to provide substantial feedback. |
|
|
遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class) | | |
|