授業の目的 【日本語】
Goals of the Course(JPN) | | |
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授業の目的 【英語】
Goals of the Course | | | The primary purpose of this course is to help students acquire a logical framework for understanding fundamental organic chemistry. This framework emphasizes how the organic molecular structures and the electron density configurations are related to patterns of chemical reactions. Based on the knowledge educated following the course contents, participants are expected to explain organic reaction sequences happening on the aliphatic substrates and solve progressive problems sequentially. |
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到達目標 【日本語】
Objectives of the Course(JPN) | | |
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到達目標【英語】
Objectives of the Course | | |
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授業の内容や構成
Course Content / Plan | | Class 1. Structure Perspective of Organic Molecules --- Atomic Electron Configuration and Construction of Organic Molecules (Hybridization).
Class 2. Projection of Molecular Structures of Organic Molecules and Classification of the Isomers --- Constitutional (Chain, Position, and Functional Group) Isomers and Stereoisomers (Diastereomers and Enantiomers).
Class 3. Optical Activities of Stereoisomers and Assignment of Stereoisomeric Structures --- Fischer and Newman Projections; Absolute (R/S) and Optically Observed (D/L) Rotations; Specific Rotation and Enantiomeric Purity; Meso Compound.
Class 4. Electron Density Configuration of Organic Molecules and Their Acidity/Basicity --- Formal Charges and Oxidation States; Acidity/Basicity and Electrophilicity/Nucleophilicity; Type of Chemical Reactions.
Class 5. Potential Energy Profiles for Kinetically and Thermodynamically Favorable Reactions --- Stability of Carbocations, Carbanions, Hydrocarbon Radicals, and the Stabilization Factors (Hyperconjugation and Resonance).
Class 6. Assessment of the Classes 1-5 with Practice Problems.
Class 7. General Trends of Aliphatic Nucleophilic Substitutions and Bimolecular Reactions (SN2) --- Efficient Substrates and Proper Leaving Groups; Reactivity of Nucleophiles and Solvent Effect; Stereochemistry; Competing Reactions.
Class 8. Unimolecular Aliphatic Nucleophilic Substitutions (SN1) --- Efficient Substrates and Proper Leaving Groups; Nucleophilicity and Solvolysis; Stability of Carbocation Intermediate; Stereochemistry; Competing Reactions.
Class 9. Aliphatic Eliminations --- Unimolecular (E1 and E1CB) and Bimolecular (E2) Elimination; Thermodynamically and Kinetically favored (Zaitsev and Hofmann) Eliminations.
Class 10. Types of Nucleophiles and Haloalkanes and Their Reaction Trends/Overview (Substitutions & Eliminations).
Class 11. Assessment of the Classes 7-10 with Practice Problems.
Class 12. Nomenclature of Organic Compounds --- Saturated/Unsaturated Hydrocarbons; Functional Groups; Aromatic Hydrocarbons; Stereochemical Assignments; Fused Rings (Spiroalkanes and Bicyclo/Tricycloalkanes).
Class 13. Structures and Stereochemistry of Cycloalkanes and their Stability and Reactivity.
Class 14. Preparation of Haloalkanes (Radical Reactions) --- Potential Energy Profiles of Reaction Coordinates.
Class 15. Assessment of Overall Classes with Practice Problems (1-14). |
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履修条件・関連する科目
Course Prerequisites and Related Courses | | | Fundamentals of Chemistries I and II |
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成績評価の方法と基準
Course Evaluation Method and Criteria | | Examination [Total 70%: two midterms (20% for each) and one final (30%)] and Assignment of Homework (30%): S(x90), A(90>x80), B(80>x70), C(70>x60), and F(60>x). The assessment methods will be reconsidered due to the change of the pandemic condition.
Submission of "Course Withdrawal Request Form is necessary to withdraw the course. The student needs to contact the course instructor when the student wants to withdraw from the course. No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s). |
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教科書・テキスト
Textbook | | | Organic Chemistry: Structure and Function (Seventh Edition), Peter C. Vollhardt and Neil E. Schore, (W. H. Freeman and Company), New York, 2014, Chapters 1-7. |
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参考書
Reference Book | | | Organic Chemistry (second edition), Jonathan Clayden, Nick Greeves, and Stuart Warren (Oxford University Press), 2012 ISBN-10:0199270295. |
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課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours) | | | Students are recommended to prepare each lecture by reading the corresponding chapter in the textbook and to review it by solving the related homework questions. Each assignment is due by the start of the next class. |
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使用言語
Language Used in the Course | | |
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授業開講形態等
Lecture format, etc. | | |
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遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class) | | |
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