授業の目的 【日本語】
Goals of the Course(JPN) | | | このコースは、入門的な有機化学の理解を促進し、学生が基本的な有機化学を理解するための論理的なフレームワークを構築するのに役立つように開設されました。 |
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授業の目的 【英語】
Goals of the Course | | | This course was designed to promote an understanding of introductory organic chemistry and to help students build a logical framework for understanding fundamental organic chemistry. |
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到達目標 【日本語】
Objectives of the Course(JPN)) | | | このコースの主な目的は、学生が基本的な有機化学を理解するための論理的なフレームワークを構築するのを支援することです。 このコースでは、有機分子構造と電子密度組成が有機化学反応のパターンにどのように関連しているかを強調します。 コースの内容から学んだ知識に基づいて、分子内または分子間有機反応のメカニズムを調査し、進行性反応シーケンスの問題を解決することを求めます。 |
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到達目標 【英語】
Objectives of the Course | | | The course emphasizes how the organic molecular structures and the electron density compositions are related to patterns of organic chemical reactions. Participants are expected to investigate the mechanism of intramolecular or intermolecular organic reactions and solve the problem of progressive reaction sequences based on the knowledge learned through the course contents. |
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授業の内容や構成
Course Content / Plan | | Class 1. Structure Perspective of Organic Molecules --- Atomic Electron Configuration and Construction of Organic Molecules (Hybridization).
Class 2. Projection of Molecular Structures of Organic Molecules and Classification of the Isomers --- Constitutional (Chain, Position, and Functional Group) Isomers and Stereoisomers (Diastereomers and Enantiomers).
Class 3. Optical Activities of Stereoisomers and Assignment of Stereoisomeric Structures --- Fischer and Newman Projections; Absolute configurations(R/S) and Optically Observed (D/L) Rotations; Specific Rotation and Enantiomeric Purity; Meso Compound.
Class 4. Electron Density Configuration of Organic Molecules and Their Acidity/Basicity --- Formal Charges and Oxidation States; Acidity/Basicity and Electrophilicity/Nucleophilicity; Type of Chemical Reactions.
Class 5. Potential Energy Profiles for Kinetically and Thermodynamically Favorable Reactions --- Stability of Carbocations, Carbanions, Hydrocarbon Radicals, and the Stabilization Factors (Hyperconjugation and Resonances).
Class 6. Assessment of the Classes 1-5 with Practice Problems.
Class 7. General Trends of Aliphatic Nucleophilic Substitutions and Bimolecular Reactions (SN2) --- Efficient Substrates and Proper Leaving Groups; Reactivity of Nucleophiles and Solvent Effect; Stereochemistry; Competing Reactions.
Class 8. Unimolecular Aliphatic Nucleophilic Substitutions (SN1) --- Efficient Substrates and Proper Leaving Groups; Nucleophilicity and Solvolysis; Stability of Carbocation Intermediate; Stereochemistry; Competing Reactions.
Class 9. Aliphatic Eliminations --- Unimolecular (E1 and E1CB) and Bimolecular (E2) Eliminations; Thermodynamically and Kinetically favored (Zaitsev and Hofmann) Eliminations.
Class 10. Types of Nucleophiles and Haloalkanes and Their Reaction Trends/Overview (Substitutions & Eliminations).
Class 11. Assessment of the Classes 7-10 with Practice Problems.
Class 12. Nomenclature of Organic Compounds --- Saturated/Unsaturated Hydrocarbons; Functional Groups; Aromatic Hydrocarbons; Stereochemical Assignments; Fused Rings (Spiroalkanes and Bicyclo/Tricycloalkanes).
Class 13. Structures and Stereochemistry of Cycloalkanes and their Stability and Reactivity.
Class 14. Preparation of Haloalkanes (Radical Reactions) --- Potential Energy Profiles of Reaction Coordinates.
Class 15. Assessment of Overall Classes with Practice Problems (1-14). |
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履修条件
Course Prerequisites | | | The students who registers for this course should complete ‘Fundamentals of Chemistry I and II'. |
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関連する科目
Related Courses | | | Physical Chemistry, Quantum Chemistry |
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成績評価の方法と基準
Course Evaluation Method and Criteria | | | Examination [total 70%: two midterms (20% for each) and one final (30%)] and Assignment of Homework and Attendances (30%): A+(95), A(95>xx80), B(80>x70), C(70>x65), C-(65>x60), and F(60x) |
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不可(F)と欠席(W)の基準
Criteria for "Fail (F)" & "Absent (W)" grades | | | No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s). |
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参考書
Reference Book | | | Organic Chemistry (second edition), Jonathan Clayden, Nick Greeves, and Stuart Warren (Oxford University Press), 2012 ISBN-10:0199270295. |
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教科書・テキスト
Textbook | | | Organic Chemistry: Structure and Function (Eighth Edition), Peter K. Vollhardt and Neil Schore, (W. H. Freeman and Company), New York, 2018, Chapters 1-7. |
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課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours) | | | Students are recommended to prepare each lecture by reading the corresponding chapter in the textbook and to review it by solving the related homework questions. Each assignment should be submitted at the begin of the next class. Late or no submission of the assignment is the deduction point of the grade. |
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注意事項
Notice for Students | | The assessment methods will be reconsidered due to the change of the pandemic condition.
Whoever provides any suspicious action in any exam will lose his/her total credits of all coursework in the current semester, based on the University law. |
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他学科聴講の可否
Propriety of Other department student's attendance | | |
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他学科聴講の条件
Conditions for Other department student's attendance | | |
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レベル
Level | | |
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キーワード
Keyword | | |
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履修の際のアドバイス
Advice | | |
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授業開講形態等
Lecture format, etc. | | | This course is a lecture based course. Participants can have lecture materials for the respective classes through NUCT. |
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遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class) | | |
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