授業の目的 【日本語】
Goals of the Course(JPN) | | | このコースは、入門的な有機化学の理解を促進し、学生が基本的な有機化学を理解するための論理的なフレームワークを構築するのに役立つように開設されました。このコースの主な目的は、基本的な有機化学を理解するための論理的なフレームワークを取得することであります。 このフレームワークではπ結合を持つ有機分子の化学反応の影響を主に勉強します。 コース内容の知識に基づいて、芳香族化合物を含む不飽和有機分子で起こる有機反応シーケンスをしっかりと理解し、その進行性問題を順次解決することを求めます。 |
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授業の目的 【英語】
Goals of the Course | | | This course was designed to promote an understanding of introductory organic chemistry and to help students build a logical framework for understanding fundamental organic chemistry. The primary purpose of this course is to acquire a logical framework for understanding fundamental organic chemistry. This framework influences for chemical reactions of the organic molecules having π-bonds. Based on the knowledge of the course contents, the participants are expected to understand organic reaction sequences happening with unsaturated organic molecules, including aromatic compounds, and solve the progressive problems sequentially. |
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到達目標 【日本語】
Objectives of the Course(JPN)) | | | 本科目の目標は、有機化学の基礎を理解するための論理的な枠組みを習得することです。講義から得た知識を基に、順次的な問題を解き、単純な反応からより複雑な反応までの反応経路と反応機構を明らかにする基盤の形成を期待します。多重結合を含む不飽和有機分子場やπ電子共役を含む芳香族化合物における電子密度分布とその化学反応性に影響を与える因子を理解し、関連する一連の有機化学反応機構を論理的理解により判断する能力を身に付けることです。 |
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到達目標 【英語】
Objectives of the Course | | | The primary goal of this course is to acquire a logical framework for understanding fundamental organic chemistry. Based on the knowledge gained from the lectures, students are expected to solve sequential problems and form a foundation for clarifying reaction pathways and mechanisms from simple reactions to more complex reactions. It is aimed to understand the electron density distribution in unsaturated organic molecular fields containing multiple bonds and aromatic compounds containing π-electron conjugation and the factors affecting their chemical reactivity and to understand a series of related organic chemical reaction mechanisms logically. |
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授業の内容や構成
Course Content / Plan | | Class 1. Electron Configuration of Unsaturated Hydrocarbons and Their Reaction Trends --- Difference of Reactivity between Saturated and Unsaturated Aliphatic Hydrocarbons and Aromatic Hydrocarbons. Class 2. Nuclear Magnetic Resonance (NMR) Spectroscopy of Organic Molecules --- Level of Energy Source for Various Spectroscopy; Larmor Frequency and Quantized Energy; Spin Spinning and Applied Magnetic Field; Zeeman Effect and Resonances; Shielding and Deshielding; Downfield and Upfield; Chemical Shifts, Integration, and Peak Splitting; [N+1] rule.
Class 3. Preparations of Alkenes and Sequence of Electrophilic Additions of Alkenes --- Potential Energy Stability of Unsaturated Aliphatic Compounds and Electrophilic Additions; Preparations by E2 Elimination and Dehydration; Hydrogenation; Halogenations (toward Monohaloalkane, Dihaloalkane, Halohydrin, and Allylic halide) of Simple Alkenes and Conjugated Dienes.
Class 4. Electrophilic Additions of Alkenes --- Hydration; Carbene Addition; Oxidation; Radical Addition; Heck Coupling; Polymerization.
Class 5. Assessment of the Classes 1-4 with Practice Problems.
Class 6. Reactions of delocalized pai-systems (Diels-Alder Reactions and Electrocyclization) --- Efficient Dienes and Dienophiles; Stereochemistry in Diels-Alder Reactions (Endo/Exo cycloadditions and Endo Rule); Thermal and Photochemical Cyclization for Even- and Odd-Numbered Double Bonds.
Class 7. Preparations of Alkynes and Sequence of Electrophilic Additions of Alkenes --- Hydrogenation; Halogenation; Hydration.
Class 8. Delocalized -Systems and Reactivity of Benzene --- Stability of Extended Conjugations and the Electron Configuration of Delocalized -Systems (Nonaromatic/Aromatic/Antiaromatic Compounds); Projection of Resonances.
Class 9. The reaction of Benzene --- Electrophilic Aromatic Substitutions (Halogenation, Nitration, Sulfonation, Friedel-Crafts Alkylation, Friedel-Crafts Acylation, Wolff-Kishner and Clemmensen Reductions).
Class 10. Assessment of the Classes 6-9 with Practice Problems.
Class 11. Electrophilic Substitutions of Substituted Benzenes --- ortho & para-Directing and meta-Directing Groups and the Reactivities
Class 12. Nucleophilic Substitutions of Benzene (via Benzyne Formation or through Inductive Effects of Substituents).
Class 13. Preparations of Multiply Substituted Benzenes --- Protection/Deprotection of amine; Reduction/Oxidation.
Class 14. Electrophilic Substitutions of Fused Aromatic Compounds (Naphthalene and Anthracene). Class 15. Assessment of the Overall Classes (1-14) with Practice Problems. |
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履修条件
Course Prerequisites | | | Fundamental Chemistry I and II, and Organic Chemistry I |
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関連する科目
Related Courses | | | Organic Chemistry I and III~V |
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成績評価の方法と基準
Course Evaluation Method and Criteria | | | Examination [total 70%: two midterms (20% for each) and one Final (30%)], Attendance and Assignments (30%). GPA (Grade Point Average) grading system is based on ‘six-step’ grade scale: A+, A, B, C, C–, and F (A+: x ≧ 95, A: 95 > x ≧ 80, B: 80 > x ≧ 70, C: 70 > x ≧ 65, C–: 65 > x ≧ 60, and F: 60 > x). |
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不可(F)と欠席(W)の基準
Criteria for "Fail (F)" & "Absent (W)" grades | | | Each homework is vital for reviewing the corresponding class, whose submission is strongly encouraged before the beginning of the next lesson. Late or no assignment submission is the deduction point of the grade. |
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参考書
Reference Book | | |
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教科書・テキスト
Textbook | | |
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課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours) | | | Students are recommended to prepare each lecture by reading the corresponding chapters in the textbook and reviewing it by solving the related homework questions. NU general guideline considers the necessity of the average of 2~3 hours of personal study time per week for each credit. |
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注意事項
Notice for Students | | | Each homework is vital for reviewing the corresponding class, whose submission is strongly encouraged before the beginning of the next lesson. Late or no assignment submission is the deduction point of the grade. |
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他学科聴講の可否
Propriety of Other department student's attendance | | |
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他学科聴講の条件
Conditions for Other department student's attendance | | |
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レベル
Level | | |
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キーワード
Keyword | | |
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履修の際のアドバイス
Advice | | |
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授業開講形態等
Lecture format, etc. | | | Face-to-face course（Only face-to-face classes） |
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遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class) | | |
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