授業の目的 【日本語】
Goals of the Course(JPN) | | | このコースは、有機化学の理解を促進し、学生が主要な知識を理解するための論理的なフレームワークを構築するのに役立つように開設されました。このコースの主な目的は、基本的な有機化学を理解するための論理的なフレームワークを習得することです。 概要は、本質的に、ヒドロキシ、カルボニル、アミノ基などの重要な官能基を有する有機化合物、およびそれらの誘導体の反応を提供します。 学生達にはコースの内容から学んだ知識に基づいて、ある官能基を別の官能基に変換する有機化学反応を理解し、進行の問題を解決することが求められます。 |
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授業の目的 【英語】
Goals of the Course | | | This course was designed to promote an understanding of organic chemistry and to help students build a logical framework for understanding the principle knowledge. The primary purpose of the course is to master a logical framework for understanding fundamental organic chemistry. The outlines essentially provide the reactions of the organic compounds having critical functional groups, such as hydroxy, carbonyl, and amino groups, as well as their derivatives. Students are expected to understand the organic chemical reactions transforming one functional group into another and solve progression problems based on the knowledge learned through the course contents. |
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到達目標 【日本語】
Objectives of the Course(JPN)) | | | このコースは、有機化学の理解を促進し、学生が主要な知識を理解するための論理的なフレームワークを構築するのに役立つように開設されました。このコースの主な目的は、基本的な有機化学を理解するための論理的なフレームワークを習得することです。 概要は、本質的に、ヒドロキシ、カルボニル、アミノ基などの重要な官能基を有する有機化合物、およびそれらの誘導体の反応を提供します。 学生達にはコースの内容から学んだ知識に基づいて、ある官能基を別の官能基に変換する有機化学反応を理解し、進行の問題を解決することが求められます。 |
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到達目標 【英語】
Objectives of the Course | | | This course was designed to promote an understanding of organic chemistry and to help students build a logical framework for understanding the principle knowledge. The primary purpose of the course is to master a logical framework for understanding fundamental organic chemistry. The outlines essentially provide the reactions of the organic compounds having critical functional groups, such as hydroxy, carbonyl, and amino groups, as well as their derivatives. Students are expected to understand the organic chemical reactions transforming one functional group into another and solve progression problems based on the knowledge learned through the course contents. |
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授業の内容や構成
Course Content / Plan | | Class 1 & 2. Alcohols and Ethers --- Acidity/Basicity of Alcohols; Preparation of Alcohols (Nucleophilic Substitutions (SN1 & SN2), Reduction of Carbonyl Compounds, Hydrolysis of Esters); Reaction of Alcohols (Deprotonation, Substitution, Elimination, Oxidation, Inorganic Ester Formation); Preparation of Ethers (Williamson Ether Synthesis) and Reaction of Ethers.
Class 3. Esters --- Inorganic and Organic Esters; Haloalkane Formation from Alcohols via Inorganic Esters; Reaction of Organic Esters (Hydrolysis, Lactones into Open Chain Esters, Esters into Amides and Alcohols, Reduction).
Class 4. Acyl Halide --- Reactivity of Carbonyl Compounds (Leaving Ability of Leaving Groups); Reaction of Acyl Halides (Conversion into Carboxylic acid, Anhydride, Ester, Amide, Ketone, Aldehyde, and Phenylalkanone).
Class 5. Aldehydes and Ketones --- Preparations of Aldehydes and Ketones (Oxidation of Alcohols, Ozonolysis of Alkenes, Hydration of Alkynes; Friedel-Grafts Acylation)
Class 6. Reactions of Aldehydes and Ketones --- Grignard Reaction; Hydration (in acid/base); Acetalization/Deacetalization; Thioacetalization/Dethioacetalization/Desulfurization.
Class 7. Reactions of Aldehydes and Ketones --- Conversions into Cyanohydrin; Wittig Reaction; Baeyer-Villiger Oxidation; Conversion into Imine, Oxime, and Hydrazone; Reduction of Acyl Compounds into Alkanes.
Class 8. Assessment of the Classes 1-7 with Practice Problems.
Class 9. Enols and Enolates --- Reactivity and Reaction Trends of Carbonyl Compounds in Acid and Base
Class 10. Reactivities of Formaldehyde, Aldehydes, and Ketones and Their Reactions --- Reactions with Amines (into Imine, Iminium, and Enamine) and Reaction Comparison; Mannich Reaction.
Class 11. Reactions of Conjugated Aldehydes, Ketones, --- Preparation of Conjugated Carbonyl Compounds; 1,2-addition versus 1,4-addition; Soft and Hard Base Nucleophiles; Michael Additions; Robinson Annulation.
Class 12. Carboxylic Acids --- Preparation of Carboxylic acids (Alcoholysis, Hydrolysis, Over Oxidation of Primary Alcohols, Reduction of CO2, Conversion of Nitrile into Carboxylic Acid).
Class 13. Reactions of Carboxylic Acids --- Hell-Volhard-Zelinsky Bromination; Acyl Chloride Formation; Anhydride Formation; Decarboxylation.
Class 14. Intermolecular/Intramolecular Cross Condensations --- Aldol Condensation; Claisen Condensation; Retro-Claisen Condensation; Dieckmann Condensation.
Class 15. Assessment of Overall Classes (1-14) with Practice Problems. |
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履修条件
Course Prerequisites | | | Fundamentals of Chemistry I and II, and Organic Chemistry I and II |
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関連する科目
Related Courses | | | Organic Chemistry I~II and IV~V, Bioorganic Chemistry |
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成績評価の方法と基準
Course Evaluation Method and Criteria | | | Examination [total 70%: midterm (30%) and final (40%)] and Assessment of Homework and Attendances (30%): S(x≧90), A(90>x≧80), B(80>x≧70), C(70>x≧60), and F(60>x) for the students who entered earlier than 2020; A+(≧95), A(95>x≧x80), B(80>x≧70), C(70>x≧65), C-(65>x≧60), and F(60＞x) for the students who entered in 2020 or later than 2020. |
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不可(F)と欠席(W)の基準
Criteria for "Fail (F)" & "Absent (W)" grades | | | In the cases of any unavoidable reasons such as sickness, accident, or no attendance school, the student may get a grade of 'Absent' through the judgment of the course instructor and the student when the student submits a 'Course Withdrawal Request Form' to receive the 'Absent' grade. No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s). |
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参考書
Reference Book | | | Organic Chemistry (eighth edition, Global edition), Paula Yurkanis Bruice (Pearson), 2017 ISBN 10: 1-292-16034-9 |
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教科書・テキスト
Textbook | | | Organic Chemistry: Structure and Function (Eighth Edition), Peter K. Vollhardt and Neil Schore, (W. H. Freeman and Company), New York, 2018, Chapters 8-9, and 17-20. |
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課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours) | | | Students are recommended to prepare each lecture by reading the corresponding chapters in the textbook and reviewing it by solving the related homework questions. Each assignment is due by the start of the next class. Late or no assignment submission is the deduction point of the grade. NU general guideline considers the necessity of the average of 2~3 hours of personal study time per week for each credit. |
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注意事項
Notice for Students | | |
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他学科聴講の可否
Propriety of Other department student's attendance | | |
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他学科聴講の条件
Conditions for Other department student's attendance | | |
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レベル
Level | | |
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キーワード
Keyword | | |
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履修の際のアドバイス
Advice | | |
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授業開講形態等
Lecture format, etc. | | | Face-to-face course（Only face-to-face classes） |
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遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class) | | |
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