授業の目的 【日本語】
Goals of the Course(JPN) | | | このコースは、有機化学の理解を促進し、学生が主要な知識を理解するための論理的なフレームワークを構築するのに役立つように開設されました。具体的に有機化学３では、ヒドロキシ、カルボニル、エステル、エテル、アミン基などの重要な官能基を含む有機化合物、およびそれらの誘導体の反応とを反応メカニズムを学び、ある官能基を他の官能基に変換する有機化学反応と、その化学反応性の明らかな理解を本授業の目的とします。 |
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授業の目的 【英語】
Goals of the Course | | | The purpose of this course is to build a logical framework of organic chemistry and grasp the principle knowledge. The course outlines typical reactions of organic compounds with specific functional groups, such as hydroxy, carbonyl, and amino groups, and their extended derivatives like acyl halide, esters, carboxylic acids, and amides. Students are able to indicate each chemical reaction, transforming one functional group into another, and solve the progressive questions. |
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到達目標 【日本語】
Objectives of the Course(JPN)) | | | このコースの主な目的出あるようにヒドロキシ、カルボニル、エステル、エテル、アミン基などの重要な官能基を含む有機化合物、およびそれらの誘導体の化学反応とその反応性を学び 基本的な有機化学を理解するための論理的なフレームワークを習得します。最終的には異なる官能基の変換に伴う有機化学反応の理解問題やその進行問題の解決が可能となります。 |
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到達目標 【英語】
Objectives of the Course | | | This course aims to gain a logical framework for understanding organic chemistry and sufficient molecular functional groups controlling chemical reactions and their reactivities, eventually identifying the proper reaction sequences to transform one functional group into another and solve the related chemistry problems, simple to complicated. |
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授業の内容や構成
Course Content / Plan | | Class 1 & 2. Alcohols and Ethers --- Acidity/Basicity of Alcohols; Preparation of Alcohols (Nucleophilic Substitutions (SN1 & SN2), Reduction of Carbonyl Compounds, Hydrolysis of Esters); Reaction of Alcohols (Deprotonation, Substitution, Elimination, Oxidation, Inorganic Ester Formation); Preparation of Ethers (Williamson Ether Synthesis) and Reaction of Ethers.
Class 3. Esters --- Inorganic and Organic Esters; Haloalkane Formation from Alcohols via Inorganic Esters; Reaction of Organic Esters (Hydrolysis, Lactones into Open Chain Esters, Esters into Amides and Alcohols, Reduction).
Class 4. Acyl Halide --- Reactivity of Carbonyl Compounds (Leaving Ability of Leaving Groups); Reaction of Acyl Halides (Conversion into Carboxylic acid, Anhydride, Ester, Amide, Ketone, Aldehyde, and Phenylalkanone).
Class 5. Aldehydes and Ketones --- Preparations of Aldehydes and Ketones (Oxidation of Alcohols, Ozonolysis of Alkenes, Hydration of Alkynes; Friedel-Grafts Acylation)
Class 6. Reactions of Aldehydes and Ketones --- Grignard Reaction; Hydration (in acid/base); Acetalization/Deacetalization; Thioacetalization/Dethioacetalization/Desulfurization.
Class 7. Reactions of Aldehydes and Ketones --- Conversions into Cyanohydrin; Wittig Reaction; Baeyer-Villiger Oxidation; Conversion into Imine, Oxime, and Hydrazone; Reduction of Acyl Compounds into Alkanes.
Class 8. Assessment of Classes 1-7 with Practice Problems.
Class 9. Enols and Enolates --- Reactivity and Reaction Trends of Carbonyl Compounds in Acid and Base
Class 10. Reactivities of Formaldehyde, Aldehydes, and Ketones and Their Reactions --- Reactions with Amines (into Imine, Iminium, and Enamine) and Reaction Comparison; Mannich Reaction.
Class 11. Reactions of Conjugated Aldehydes, Ketones, --- Preparation of Conjugated Carbonyl Compounds; 1,2-addition versus 1,4-addition; Soft and Hard Base Nucleophiles; Michael Additions; Robinson Annulation.
Class 12. Carboxylic Acids --- Preparation of Carboxylic acids (Alcoholysis, Hydrolysis, Over Oxidation of Primary Alcohols, Reduction of CO2, Conversion of Nitrile into Carboxylic Acid).
Class 13. Reactions of Carboxylic Acids --- Hell-Volhard-Zelinsky Bromination; Acyl Chloride Formation; Anhydride Formation; Decarboxylation.
Class 14. Intermolecular/Intramolecular Cross Condensations --- Aldol Condensation; Claisen Condensation; Retro-Claisen Condensation; Dieckmann Condensation.
Class 15. Assessment of Overall Classes (1-14) with Practice Problems. |
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履修条件
Course Prerequisites | | | The student should complete the prerequisite courses (Fundamentals of Chemistry I and II, and Organic Chemistry I and II). |
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関連する科目
Related Courses | | | Chemistry Laboratory, Graduation Research, Polymer Chemistry |
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成績評価の方法と基準
Course Evaluation Method and Criteria | | | Examination [total 70%: midterm (30%) and final (40%)] and Assessment of Homework and Attendances (30%): A+(≧95), A(95>x≧x80), B(80>x≧70), C(70>x≧65), C-(65>x≧60), and F(60＞x). |
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不可(F)と欠席(W)の基準
Criteria for "Fail (F)" & "Absent (W)" grades | | | No submission of sickness/absence reports and lack of attendance score will result in an 'F' grade: It is for the protection of other attendances in the corresponding course from the frequent absences of the specific/uncertain student(s). |
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参考書
Reference Book | | | Organic Chemistry (eighth edition, Global edition), Paula Yurkanis Bruice (Pearson), 2017 ISBN 10: 1-292-16034-9, Chapters 10, 15-17. |
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教科書・テキスト
Textbook | | | Organic Chemistry: Structure and Function (Eighth Edition), Peter K. Vollhardt and Neil Schore, (W. H. Freeman and Company), New York, 2018, Chapters 8-9, and 17-20. |
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課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours) | | | Students are recommended to prepare each lecture by reading the corresponding chapters in the textbook and reviewing it by solving the related homework questions. NU general guideline considers the necessity of the average of 2~3 hours of personal study time per week for each credit. |
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注意事項
Notice for Students | | | Students are recommended to review the lectures by solving the related homework questions. Each assignment is due by the start of the next class. Late or no assignment submission is the grade's deduction point. |
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他学科聴講の可否
Propriety of Other department student's attendance | | |
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他学科聴講の条件
Conditions for Other department student's attendance | | |
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レベル
Level | | |
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キーワード
Keyword | | |
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履修の際のアドバイス
Advice | | |
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授業開講形態等
Lecture format, etc. | | | Face-to-face course（対面授業） |
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遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class) | | |
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