学部・大学院区分
Undergraduate / Graduate		理・博前
時間割コード
Registration Code		2680544
科目区分
Course Category		前期専門科目
MC Specialized Course
科目名　【日本語】
Course Title		[G30] 生体物理学特別講義
科目名　【英語】
Course Title		[G30] Special Lecture on Biophysics
コースナンバリングコード
Course Numbering Code
担当教員　【日本語】
Instructor		内橋 貴之 ○ 村田 武士
担当教員　【英語】
Instructor		UCHIHASHI Takayuki ○ MURATA Takeshi
単位数
Credits		1
開講期・開講時間帯
Term / Day / Period		春集中 その他 その他
Intensive(Spring) Other Other
授業形態
Course style		講義
Lecture
学科・専攻
Department / Program
必修・選択
Required / Selected


授業の目的　【日本語】
Goals of the Course(JPN)
授業の目的　【英語】
Goals of the Course
More than 60% of drug discovery targets are membrane proteins, but it is still difficult to obtain their 3D structural information. The current status of 3D structural analysis of membrane proteins will be presented.
到達目標　【日本語】
Objectives of the Course(JPN))
到達目標　【英語】
Objectives of the Course
The objective of this course is to understand the current status of structural analysis of drug discovery-related proteins and structure-based drug discovery. The goal is to learn how to use Pymol, a protein structure display program, and to be able to create a protein structure diagram of a grade that can actually be used in an academic paper.
授業の内容や構成
Course Content / Plan
1: Self-Introduction, Laboratory Introduction
2: What is a protein?
3: What is structural analysis?
4: What is Drug Discovery 1
5: What is Drug Discovery 2
6: What is Drug Discovery 3
7: Expression and Purification of Drug Targets
8: Production of structure-recognition antibodies against drug targets
9. X-ray crystallographic analysis of drug targets
10: Cryo-EM analysis of drug targets
11. Protein structure database (PDB)
12th: Rewriting of PDB files
13. How to use Pymol, a structure display program (1)
14. How to use Pymol 2
15. How to write a report 1
16. How to write a report 2
履修条件
Course Prerequisites
none
関連する科目
Related Courses
Biophysics II
成績評価の方法と基準
Course Evaluation Method and Criteria
Translate the assigned protein structure analysis paper.
In this case, protein structure diagrams will be created by each student using Pymol.
The grading will be based on the skill of the protein structure diagram. Grading will be based on the skill of the figure creation.
The deadline for submission is one month.
教科書・テキスト
Textbook
None
参考書
Reference Book
Biochemistry, Donald Voet, Judith G. Voet
課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours)
Explore the Internet to acquire related knowledge about the course content.
注意事項
Notice for Students
他学科聴講の可否
Propriety of Other department student's attendance
他学科聴講の条件
Conditions of Other department student's attendance
レベル
Level
キーワード
Keyword
履修の際のアドバイス
Advice
授業開講形態等
Lecture format, etc.
face-to-face
遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class)