授業の目的 【日本語】
Goals of the Course(JPN) | | | 本科目では、入門的な有機化学の理解を目標とし、学生が基本的な有機化学を容易に理解できる論理的枠組みを構築できるよう開講されました。まず学生は、有機分子の構造と電子密度分布が有機化学反応パターンとどのように相互に関連しているかを学び、その知識に基づき分子内部または分子間で起こる有機反応のパターンを理解し、進行性反応メカニズムに関する問題を解決できるようになります。[G30プログラム科目] |
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授業の目的 【英語】
Goals of the Course | | | This course aims to provide an introductory understanding of organic chemistry, enabling students to construct a logical framework for easily grasping fundamental organic chemistry concepts. Students will first learn how the structure of organic molecules and their electron density distribution are interrelated with organic chemical reaction patterns. Based on this knowledge, students will understand the patterns of organic reactions occurring within or between molecules and be able to solve problems concerning progressive reaction mechanisms. |
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到達目標 【日本語】
Objectives of the Course(JPN) | | | 学生がより効果的に有機化学を理解できる基礎的な論理的枠組みを構築することを目的とします。学生は、原子の電子配置と混成、軌道間の相互作用による多様な分子構造と形成・安定化、そしてそこで起こる化学反応および付随する競合反応について学びます。これにより古典的な反応メカニズムへの理解を習得し、関連する演習問題を通じて有機分子間または有機分子内で進行する有機反応の基本パターンを区別できるようになります。[G30プログラム科目] |
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到達目標【英語】
Objectives of the Course | | | The objective is to establish a fundamental logical framework enabling students to understand organic chemistry more effectively. Students will learn about diverse molecular structures and their formation and stabilization through atomic electron configurations and hybridization, interorbital interactions, and the chemical reactions occurring therein, along with associated competing reactions. This will equip students with an understanding of classical reaction mechanisms and, through related exercise problems, enable them to distinguish basic patterns of organic reactions occurring between or within organic molecules. |
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授業の内容や構成
Course Content / Plan | | Class 1. Structure Perspective of Organic Molecules --- Atomic Electron Configuration and Construction of Organic Molecules (Hybridization).
Class 2. Projection of Molecular Structures of Organic Molecules and Classification of the Isomers --- Constitutional (Chain, Position, and Functional Group) Isomers and Stereoisomers (Diastereomers and Enantiomers).
Class 3. Optical Activities of Stereoisomers and Assignment of Stereoisomeric Structures --- Fischer and Newman Projections; Absolute configurations(R/S) and Optically Observed (D/L) Rotations; Specific Rotation and Enantiomeric Purity; Meso Compound.
Class 4. Electron Density Configuration of Organic Molecules and Their Acidity/Basicity --- Formal Charges and Oxidation States; Acidity/Basicity and Electrophilicity/Nucleophilicity; Type of Chemical Reactions.
Class 5. Potential Energy Profiles for Kinetically and Thermodynamically Favorable Reactions --- Stability of Carbocations, Carbanions, Hydrocarbon Radicals, and the Stabilization Factors (Hyperconjugation and Resonances).
Class 6. Assessment of Classes 1-5 with Practice Problems.
Class 7. General Trends of Aliphatic Nucleophilic Substitutions and Bimolecular Reactions (SN2) --- Efficient Substrates and Proper Leaving Groups; Reactivity of Nucleophiles and Solvent Effect; Stereochemistry; Competing Reactions.
Class 8. Unimolecular Aliphatic Nucleophilic Substitutions (SN1) --- Efficient Substrates and Proper Leaving Groups; Nucleophilicity and Solvolysis; Stability of Carbocation Intermediate; Stereochemistry; Competing Reactions.
Class 9. Aliphatic Eliminations --- Unimolecular (E1 and E1CB) and Bimolecular (E2) Eliminations; Thermodynamically and Kinetically favored (Zaitsev and Hofmann) Eliminations.
Class 10. Types of Nucleophiles and Haloalkanes and Their Reaction Trends/Overview (Substitutions & Eliminations).
Class 11. Assessment of Classes 7-10 with Practice Problems.
Class 12. Nomenclature of Organic Compounds --- Saturated/Unsaturated Hydrocarbons; Functional Groups; Aromatic Hydrocarbons; Stereochemical Assignments; Fused Rings (Spiroalkanes and Bicyclo/Tricycloalkanes).
Class 13. Structures and Stereochemistry of Cycloalkanes and their Stability and Reactivity.
Class 14. Preparation of Haloalkanes (Radical Reactions) --- Potential Energy Profiles of Reaction Coordinates.
Class 15. Assessment of Overall Classes with Practice Problems (1-14). |
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履修条件・関連する科目
Course Prerequisites and Related Courses | | ・The student should complete Fundamentals of Chemistry I and II as prerequisites.
・This course strongly recommends that students who wish to attend the lectures register for the course.
・This course is advanced to Organic Chemistry 2~5. |
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成績評価の方法と基準
Course Evaluation Method and Criteria | | ・Examination [total 70%: two midterms (20% for each) and one final (30%)] and Assignment of Homework and Attendances (30%): A+(≧95), A(95>x≧x80), B(80>x≧70), C(70>x≧65), C-(65>x≧60), and F(60＞x).
・If the total score of the examinations [70%: two midterms (20% for each) and one final (30%)] and the assignment of homework and attendances (30%) is lower than 60, the student will receive an ‘F’ grade: i) Attendance is necessary for the successful completion of this course, and thus, absence will result in a reduction of points. ii) Students must submit each homework by the beginning of the next class, as it is vital for reviewing the corresponding lesson. Submitting homework late or not at all results in a point deduction.
・Submission of the "Course Withdrawal Request Form is necessary to withdraw from the course. The student needs to contact the course instructor to withdraw from the course. Failure to submit sickness/absence reports and to maintain attendance score will result in an 'F' grade. It is for the protection of other attendants in the corresponding course from the frequent absences of the specific/uncertain student(s). |
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教科書・テキスト
Textbook | | | Organic Chemistry: Structure and Function (Eighth Edition), Peter K. Vollhardt and Neil Schore, (W. H. Freeman and Company), New York, 2018, Chapters 1-7. |
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参考書
Reference Book | | | Organic Chemistry (eighth edition, Global edition), Paula Yurkanis Bruice (Pearson), 2017 ISBN 10: 1-292-16034-9, Chapters 1-5, 9, and 12(1-5). |
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課外学習等（授業時間外学習の指示）
Study Load(Self-directed Learning Outside Course Hours) | | ・Students are recommended to prepare each lecture by reading the corresponding chapters in the textbook and reviewing them by solving the related homework questions. NU general guidelines consider the necessity of an average of 2~3 hours of personal study time per credit.
・Students are recommended to review the lectures by solving the homework questions related to them. Each assignment is due at the start of the next class unless there is a special announcement. Late or missing assignment submissions result in a grade deduction.
・Participants can access lecture materials for each lesson through NUCT.
・The course instructor may ask students pop-up questions during lectures to provide substantial feedback. |
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使用言語
Language Used in the Course | | |
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授業開講形態等
Lecture format, etc. | | |
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遠隔授業（オンデマンド型）で行う場合の追加措置
Additional measures for remote class (on-demand class) | | |
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